Cardinals expect improving Murphy to contribute ri

first_img Cardinals expect improving Murphy to contribute right away Nevada officials reach out to D-backs on potential relocation Top Stories D-backs president Derrick Hall: Franchise ‘still focused on Arizona’ Comments   Share   center_img Defensive tackle Darnell Dockett said all is calm on the complaint front at the Arizona Cardinals camp in Flagstaff.“I just like the attitude of the guys this year,” Dockett said. “Everybody’s doing their job, no one’s complaining, everyone’s working.”Thanks to the lockout, everyone reported to camp a little more out of shape than normal and Whisenhunt is taking measures to get his team back in shape. What an MLB source said about the D-backs’ trade haul for Greinke “We go in there and look at our workouts and there’s like 20 things to do in the morning. Normally it would be like six to eight,” Dockett said.Conditioning has taken place every day after practice, no matter what happened during practice and the guys are going with it, Dockett said. “We just said, ‘Alright coach, whatever you want us to do’,” Dockett said.The fact that the Cardinals most outspoken player has said that all is well in camp could be huge to the team, who apparently slacked off last year.“Last year, we worked hard to get to a certain level but I feel like a lot of guys didn’t buy into the program and do everything that was tolerated by our team to win,” Dockett said.last_img read more

June 29 2017Here is 62917 The Goodwin fire sta

first_imgJune 29, 2017Here is 6/29/17 The Goodwin fire started on June 24. 2017 in the Bradshaw Ranger District of the Prescott National Forest, about 14 miles south of Prescott, Arizona.6/26 report: The Goodwin Fire continues to burn in very rugged terrain to the south and west of the junction with Senator Highway (FR 52) and County Road 177. Fire crews have been working to keep the fire south of County Road 177, the Mayer-Goodwin Road, and away from the homes and communities to the north. So far they have been successful as the fire has been burning mostly eastward toward the 2015 SA Hill Fire scar. Yesterday the fire burned up and over Brady Butte.At that time 6 hotshot crews, 10 Type II crews, 29 engines, 6 helicopter and 2 attack planes were involved, altogether 525 personnel.Vigorous winds made the firefight very difficult and on 6/27, the towns of Mayer and Poland Junction, and some of the smaller communities in the area were evacuated and as of yet there is no news when people might be able to return to their homes.Our hearts go out to our neighbors with out very best wishes. Donations of food and clothing are gathered at the FAMILY DOLLAR at Cordes Junction.On 6/26 the fire was about 8 miles north-west of Arcosanti and moving in a north-east direction.The smoke plume casts a strange light over the Arcosanti building.Highway 69 has been closed since 6/27, from the Highway 17 junction all the way to Dewey.Latest reports can be seen on the wildfire link and on the local news channels.The fire is still growing and only about 1% contained.last_img read more

Plan to support Michigans mining industry clears House

first_img State Rep. Beau LaFave, of Iron Mountain, and State Rep. Greg Markkanen, of Hancock, today announced that a plan to support the mining industry has cleared a major hurdle.The plan, House Bill 4227, establishes a commission to help increase mining opportunities in Michigan. The legislation is a product of the Upper Peninsula’s state representatives working together to bring policies that work for the region’s economy and residents.“Our core mining industry has been hampered by a lack of coordination among stakeholders, regulators and communities, and I look forward to the implementation of a committee to put an end to those roadblocks,” Markkanen said. “This advisory committee would help us bridge the gap and bring more quality jobs to our communities.”LaFave noted that this plan next goes to the Senate for approval before it reaches the governor’s desk.“Through bipartisan cooperation, we have an opportunity to grow this important industry right here in Michigan. Mining is both part of our Upper Peninsula history and crucial for making our modern lifestyle possible,” LaFave said. “From the raw materials for infrastructure projects to the minerals needed to build computers and cell phones, we count on mines for these resources. This advisory committee is intended to bolster this important industry, protect our natural resources and keep our workers and communities safe.”The proposal would create a two-year, fifteen-member advisory committee charged with developing recommendations to:Evaluate government policies that affect the mining and minerals industries.Develop public policy strategies to enhance the growth of the mining industry.Advise and bolster partnerships between industry, institutions, funding groups, environmental groups and state and federal agencies.The plan was approved overwhelmingly by the House, 107-1, and next moves to the Senate for consideration. Categories: LaFave News 21May Plan to support Michigan’s mining industry clears Houselast_img read more

German cable industry technology specialist WISI h

first_imgGerman cable industry technology specialist WISI has made a strategic investment in Canadian video processing specialist Inca Systems.WISI said that the pair will work together on the global development and delivery of linear IP video and over-the-top multiscreen solutions, including project focus on HEVC video compression, network DVR, confidence monitoring and personalised ad insertion.In addition both companies will take advantage of their existing sales networks.WISI will become the exclusive distributor for Inca’s video transcoding and multiscreen products in Europe, Asia, South America, Africa and the Middle East while Inca Networks will become the exclusive North American partner for WISI’s modular RF/IP platforms, Chameleon, Tangram, and the Optopus FTTH product range.WISI executives will also be joining the Inca board of directors.last_img read more

Researchers find crucial inhibitory role for signal peptide in GluK1 trafficking

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Nov 19 2018Glutamate is the major excitatory neurotransmitter in the brain, and the postsynaptic expression level of glutamate receptors is a critical factor in determining the efficiency of information transmission and the activity of the neuronal network. Therefore, glutamate receptor trafficking is critical to the physiological function of human brain circuitry.It is known that KAR-type glutamate receptors are closely related to many neurological disorders. Dr. SHENG Nengyin at the Kunming Institute of Zoology of the Chinese Academy of Sciences has long been devoted to studying the regulation of KAR trafficking. His previous studies have revealed that in neurons the trafficking performance of KAR subunits GluK1 and GluK2 are totally different, and it is the amino acid sequences of their extracelluar domains that determine their distinct trafficking capability.To resolve the molecular machinery, the “Neural Synaptic Mechanism and Function” group led by Dr. SHENG Nengyin, in collaboration with Dr. SHI Yun’s Lab at the Model Animal Research Center of Nanjing University, made serial chimeric GluK1-GluK2 receptors based on their conserved structures. The study was published in Nature Communications.Researchers applied electrophysiological techniques to hippocampal slice cultures to analyze the synaptic responses mediated by these receptors. They unexpectedly found a crucial inhibitory role for the signal peptide in GluK1 trafficking.Signal peptides are N-terminal residues of newly synthesized secretory or membrane proteins. Generally, they are regarded as “cellular address codes” for intracellular trafficking, localization and secretion.When GluK1 signal peptide was replaced by that of GluK2, GluK2 signal peptide reversed the previous synaptic trafficking incapability. The resultant GluK1 (SPGluK2) receptor potentiated synaptic responses similar to wild-type GluK2, and this potentiation was suppressed by coexpressed GluK1 signal peptide in the same neurons.Related StoriesTargeted breast cancer therapy shows ‘encouraging’ resultsLiving with advanced breast cancerResearchers develop DNA nanorobots that target breast cancer cellsFurthermore, they found that the inhibitory function of GluK1 signal peptide requires the presence of the N-terminal domain, since GluK1 successfully trafficked to synapses and neuronal surfaces if the N-terminal domain was replaced with the corresponding sequences of GluK2.Biochemical studies revealed that GluK1 signal peptide directly interacts with its N-terminal domain (ATD). Therefore, the researchers proposed a model whereby the cleaved signal peptide, in a trans manner and behaving as a ligand of GluK1, binds to GluK1 ATD and forms an inhibitory complex regulating GluK1 forward trafficking in neurons.This study has revealed a signal peptide function for glutamate receptor trafficking and uncovered a novel trafficking mechanism for glutamate receptors. It provides the theoretical basis for further study of synaptic transmission and plasticity, as well as the pathological mechanism of related neurological disorders.The human brain has around 10 billion neurons. The neural synapses are the basic connection units transferring information between them. Neurotransmitters, which are released by presynaptic neurons, diffuse into the synaptic cleft and bind to the corresponding receptors on postsynaptic neurons. By doing so, they regulate neuronal activity and accomplish information transmission. Any deregulation of this process is regarded as a leading cause of neurological disorder. Source: read more

I Am and I Will The Steps We Can All Take This

first_imgWhere can readers find more information?You can find out more about the UICC and our key events by visiting our website, or to find out more about World Cancer Day, click here.About World Cancer Day 2019World Cancer Day takes place every year on 4 February and is the uniting global initiative under which the world comes together to raise the profile of cancer in a positive and inspiring way. Spearheaded by the Union for International Cancer Control (UICC), the day aims to save millions of preventable deaths each year by raising awareness and improving education about the disease alongside calling on governments and individuals across the world to take action.2019 will be the first year of the new three-year campaign, ‘I Am and I Will’. The new theme is an empowering call for personal commitment and represents the power of our actions taken now to reduce the growing impact of cancer. This year follows on the back of last year’s tremendous campaign success, including nearly 1,000 activities taking place in 130 countries, over half a million tweets, and more than 50 governments participating in 2018.#WorldCancerDay #IAmAndIWillAbout the Union for International Cancer Control (UICC)The Union for International Cancer Control (UICC) is the largest and oldest international cancer-fighting organisation. Founded in Geneva in 1933, UICC has over 1,100 members in 170 countries, enjoys consultative status with the United Nations (ECOSOC) and has official relations with the following institutions: WHO, IARC, IAEA, UNODC. UICC has over 50 partners, including associations working to fight cancer, as well as companies and foundations. UICC is a founding member of the NCD Alliance, McCabe Centre and ICCP.UICC’s mission is to unite and support the cancer community to reduce the global cancer burden, to promote greater equality and to ensure that the cancer control continues to be a priority in the world health and development agenda. Its main areas of activity focus on convening the world’s leaders for innovative, wide-reaching, cancer-control events and initiatives; building capacity to meet regional needs; and developing awareness campaigns. Interview conducted by Kate Anderton, B.Sc. (Editor)Feb 4 2019 insights from industryCary AdamsCEOUnion for International Cancer Control (UICC)News-Medical speaks to Cary Adams, CEO of the charity that helped to start the annual World Cancer Day, about the reasons why cancer is still such a huge global issue, and the meaning behind the slogan: I Am And I Will.How big of a global issue is cancer?Unfortunately, cancer is still one of the largest public health issues facing our world today. Last year, we saw an estimated 18.1 million new cases of cancer as well as 9.6 million cancer deaths – 70% of which occurred in developing countries.Romolo Tavani | ShutterstockAt the current rate, deaths from cancer worldwide are projected to reach over 13 million by 2030. That’s simply unacceptable. We must continue to push for substantive change at the global and national level to significantly reduce the burden of cancer now to improve our future.What are the greatest barriers to early cancer diagnosis, treatment, and prevention around the world?There are significant barriers at the health system and governmental level which prevent millions of people around the world from accessing effective prevention information, early diagnosis, and better treatment. At the individual level, factors including age, gender, socioeconomic status, and feelings of fear or shame can prevent help-seeking behavior when someone might suspect cancer.Health systems with limited access to pathology services and diagnostic technologies can also be disadvantaged when it comes to delivering timely cancer diagnoses and treatment, particularly in low-income countries.We’re also still seeing inconsistencies between the ambitious commitments to tackle cancer being made by governments and the demonstratable action being taken to put in place effective and resource appropriate policies to boost cancer prevention, improve early detection and diagnosis rates, and ensure the best possible treatment and care.Why did UICC decide to start a World Cancer Day?When World Cancer Day was created at the World Summit Against Cancer in Paris, on 4 February 2000, its goal was to provide a platform for researchers, healthcare professionals, patients, government, industry, individuals and the media to build an invincible alliance against cancer and its greatest allies – fear, ignorance and complacency.Today, World Cancer Day continues to unite the whole world to raise awareness and education about cancer, as well as to inspire governments and empower individuals across the world to take action.The theme of the next three World Cancer Days is I Am and I Will. Please can you explain the meaning of this message, and how people can get involved in the campaign?The new World Cancer Day theme is a rallying cry for action. ‘I Am and I Will’ turns the spotlight on each and everyone one of us and our own commitment and actions. As cancer affects all of us, we also have the power to reduce its impact on ourselves, the people we love and the wider world.Anyone can get involved by sharing their personal commitments on social media, hosting an awareness event, writing a blog, lighting up a significant landmark, or volunteering to translate campaign materials.Photographee | ShutterstockWhat advice would you give to someone who has just been diagnosed with cancer?People often feel a loss of their sense of control over their own lives when they first receive a diagnosis of cancer. I would say that someone that has just been diagnosed with cancer should feel empowered to participate actively in decisions about their care and treatment. Many cancers can be managed and even cured, especially if they’re detected and treated as early as possible.What projects will UICC be focusing on after World Cancer Day?We’ll be looking to expand our Treatment for All advocacy campaign which calls on governments to turn their commitments to reduce the cancer burden into national action. We’ll also be looking forward to the World Cancer Leaders’ Summit 14-16 October 2019 in Kazakhstan, where the aim will be to better understand how cancer detection, treatment, and care can be scaled up to fit within the global ambition of universal health coverage.last_img read more

Watch Audi spotted performing stunt at Delhis Vijay Chowk

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