Encouraging results reported for injectable flu drug

first_img Sheridan said no significant differences in any of the efficacy end points were seen, which “was expected given the active control, small sample size, and exploratory phase 2 nature of this study.” Oct 28 news release about outpatient studyhttp://investor.shareholder.com/biocryst/ReleaseDetail.cfm?ReleaseID=343466 In the other trial, hospital patients who were seriously ill with flu were treated for 5 days with either IV peramivir or oseltamivir, with similar results in both groups, including no deaths and a median of 4.0 days to hospital discharge, the company said. Oct 27 news release about hospital studyhttp://investor.shareholder.com/biocryst/ReleaseDetail.cfm?ReleaseID=343132 Clinical stability was a composite measure based on temperature, oxygen saturation, respiratory rate, systolic blood pressure, and heart rate. For ethical reasons, the study included no placebo arm. In addition, both peramivir groups had significant improvements in a composite symptoms score, starting as early as 24 hours after treatment, the statement said. The drug was well-tolerated, with adverse-event profiles similar for the treatment and placebo groups. Hospital studyThe inpatient study was designed primarily to assess how long it would take patients with serious or life-threatening flu to become clinically stable with 5 days of treatment with peramivir or oseltamivir. The study was conducted at centers in the United States, Canada, Hong Kong, Singapore, Australia, New Zealand, and South Africa. “This phase 2 study was a critical test of peramivir, which demonstrated for the first time that a single administration of this potent neuraminidase inhibitor can be effective in treating seasonal influenza,” Dr. William P. Sheridan, chief medical officer of BioCryst, said in the news release. Secondary outcomes for all groups included no mortality, no clinical relapse, a median of 4.0 days to hospital discharge, and a median of 10.8 days to resumption of normal activities, the company reported. Sep 20, 2007, CIDRAP News story “Trial of injectable flu drug yields disappointing results” Sheridan also said that the zero mortality in the study is “an important finding worthy of follow-up,” given that a previous epidemiologic study showed a mortality rate of 10% in 219 patients who were not treated with neuraminidase inhibitors. See also: Page with link to recording of Oct 27 BioCryst teleconference (free registration required)http://investor.shareholder.com/biocryst/eventdetail.cfm?eventid=60565 Peramivir is a neuraminidase inhibitor, like the licensed antivirals oseltamivir (Tamiflu), which is taken orally, and zanamivir (Relenza), inhaled as a powder. In response to questions, he said the study was not designed to show differences between peramivir and oseltamivir. He said peramivir is important because it permits parenteral treatment of flu patients, adding, “At the ICAAC meeting the need for a parenteral drug for influenza has come up several times already. Also there’s concern about resistance to existing drugs, including oseltamivir.” The primary end point was time to alleviation of symptoms, which was 81.8 hours for the placebo group. The respective times for the 300-mg and 600-mg peramivir groups were 59.1 and 59.9 hours, both of which were significant reductions, the company said. Oct 31, 2008 (CIDRAP News) – BioCryst Pharmaceuticals Inc. reported encouraging results this week in two phase 2 trials of its injectable antiviral drug, peramivir, a potential new treatment for influenza. In one study, a single intravenous (IV) dose of peramivir in outpatients ill with flu reduced the duration of their symptoms by about 22 hours compared with a placebo group, a statistically significant difference, according to BioCryst, based in Birmingham, Ala. Neither set of results has yet been published in a peer-reviewed journal. The company described the inpatient study in a press release and a teleconference on Oct 27; the outpatient study was reported in an Oct 28 press release and a poster presentation at the 46th Interscience Conference on Antimicrobials and Chemotherapy/Infectious Diseases Society of America (ICAAC/IDSA) meeting this week in Washington, DC. Outpatient findingsThe outpatient study was sponsored and conducted in Japan by Shionogi & Co. Ltd., which in 2007 bought from BioCryst the rights to develop and market peramivir in Japan. “The time to clinical stability was 25.3 hours for all groups combined, with no statistically significant differences across treatment groups,” Sheridan reported during the Oct 27 conference call (a recording of which is available online). In the news release, Dr. Michael Ison of Northwestern University, principal investigator in the study, said, “This landmark study provides us great insight into the course of treatment for patients who are hospitalized for influenza. The results indicate a potential role for antiviral therapy, which is critical as currently there are no antivirals approved for patients hospitalized for acute serious or potentially life-threatening influenza.” The new findings come 13 months after the company reported disappointing results in an earlier phase 2 trial of the drug. In that study, flu patients who received injections of peramivir did better than a placebo group, but the difference was not significant. The company said at the time that the use of shorter needles than were used in an earlier trial probably resulted in inadequate doses. The study involved 296 patients who tested positive for influenza within 48 hours after symptom onset, BioCryst reported. The volunteers were divided into three groups, with 99 receiving 300 milligrams (mg) of peramivir IV, 97 receiving 600 mg of the drug IV, and 100 receiving an IV placebo. The investigators enrolled 122 patients who had flu confirmed by polymerase chain reaction. Of these, 41 received 75 mg of oseltamivir twice daily, 41 received 200 mg of IV peramivir twice daily, and 40 received 400 mg of IV peramivir twice daily.last_img read more

Antigraft group urges KPK to investigate preemployment card program

first_img“The appointment is also suspected of violating the provisions in the form of unfair business competition or monopoly,” Boyamin said.MAKI submitted the request for the investigation, along with supporting documents, to the KPK on Monday.Boyamin said the cost per course – between Rp 200,000 (US$13.23) and Rp 1 million – was too expensive when compared to the salaries of school teachers and college lecturers and the production cost of the course materials.“It is also way more expensive than other training courses available on YouTube or those searchable on Google, which are free and only require an internet plan,” he said.Boyamin cited Institute for the Development of Economics and Finance (Indef) researcher Nailul Huda, who said that the partners could potentially reap Rp 3.7 trillion in profit – Rp 457 billion each.With the potential profits, he estimated the companies would get 66 percent profit from the course fees, higher than the 20 percent profit limit allowed by the Supreme Audit Agency (BPK) and the Development Finance Comptroller (BPKP).Read also: ‘Preemployment card ineffective, gimmicky’, CEO participant claimsThe preemployment card program’s stated goal is to help workers and small business owners hit by the COVID-19 outbreak. It seeks to distribute Rp 20 trillion in incentives from the 2020 state budget to 5.6 million eligible recipients.About 9 million candidates have applied for the program since its launch on April 11. More than 2.2 million people have lost their jobs as of April 20 as a result of the health crisis.This is not the program’s first brush with controversy. The appointment of Ruangguru – a startup owned by President Joko “Jokowi” Widodo’s then-expert staffer Adamas Belva Syah Devara – as a private-sector partner led to Adamas’ resignation on April 21.Negative sentiment has also plagued the program, with 81 percent of the 38,000 online discussions of the program containing keywords such as “conflict of interest” and “leaked budget”, according to Indef research between March 27 and April 25.Panji Ruky, the preemployment card program’s management director of communications, however, claimed the partner-selection process was conducted fairly, without any corruption.Perbanas Institute economist Piter Abdullah has also questioned the program’s effectiveness because of the lack of hiring during the outbreak, noting that people needed cash assistance more.KPK acting spokesperson Ali Fikri said on Tuesday that the antigraft body would look into the information provided by MAKI before deciding whether to take further action.”If our analysis finds an indication of potential criminal practice, then there will be a possibility that the KPK will launch an [investigation] into the case,” he said as quoted by kompas.com.Topics : The Indonesian Anticorruption Community (MAKI) has asked the Corruption Eradication Commission (KPK) to investigate the government’s preemployment card program, particularly the lack of transparency in its selection of private-sector partners.“The appointment of the partners was allegedly conducted without a ‘beauty contest’ [competitive applications and bidding], and it did not meet the requirements of administrative and technical qualifications because there was no previous announcement of the requirements themselves,” MAKI coordinator Boyamin Bin Saiman said in a statement on Monday.  In March, the government announced that it had appointed eight digital platforms as partners in the preemployment card program – an initiative that combines cash aid and training subsidies for unemployed workers to augment the social safety net during the COVID-19 crisis. The partners announced were the Manpower Ministry, e-commerce platforms Tokopedia and Bukalapak, as well as online learning platforms Ruangguru, Pintaria, Sekolahmu, Pijarmahir and MauBelajarApa. The e-commerce platforms were responsible for the program’s marketing and sales, while the learning platforms provided the training courses – ranging from marketing to fishing – intended to develop the skills of people laid off as a result of the pandemic.Critics have criticized the partner-selection process as opaque, with no open call for applicants or transparent selection criteria.Read also: Preemployment card draws criticism as workers ‘need cash aid’last_img read more

Indian greats tip Kohli to topple all

first_imgFORMER India captains Sunil Gavaskar and Mohammad Azharuddin expect their contemporary Virat Kohli to shatter most batting records in the game after the 28-year-old toppled two cricketing legends with his double century against Bangladesh.And in an ominous warning for Australia’s bowlers, Gavaskar says “the mind just boggles” when he thinks about what Kohli could do against the Aussies in their upcoming four-Test seriesKohli’s innings of 204 in Hyderabad was the fourth time in consecutive Test series that he’d posted a double century, passing the previous record of three held by Sir Donald Bradman and Rahul Dravid.The right-hander now averages 68 from 23 Tests as India’s skipper, including nine hundreds, drawing level with Azharuddin’s mark of nine centuries from 47 Tests as skipper.Only Gavaskar stands in Kohli’s way in terms of centuries by an Indian skipper, the former opener notching 11 tons in 47 Tests in charge.And the older duo are in no doubt that the current skipper is on the path to legendary status.“He’s a great in my book,” Gavaskar told NDTV. “I think he’s on his way to becoming a legend.“That’s something which is eventually going to happen sooner rather than later.“The way he’s batting, he’s going to rewrite the whole record book.“Most of the batting records, if not all of the batting records, are going to be his the way he’s going about scoring runs and scoring big runs in all forms of the game.”Azharuddin, who scored 22 centuries in 99 Tests for India, agreed that most batting records were well within reach of a man whose thirst for runs seems unquenchable.“Records are meant to be broken and I think the form he is (in) at the moment most batting records will tumble,” Azharuddin told xtratime.in.“The hallmark of a great player is to do well in any condition and under any situation. Virat has proved that time and again in recent times.“The one thing that stays apart for me is his ability to stay focused and score runs in any format consistently.“He is well aware of what is happening and has the ability to read the situation.”Kohli’s double centuries against the West Indies, New Zealand, England (all last year) and now Bangladesh are his first in Test cricket having previously passed 150 just twice in his career.Of his nine centuries he has scored as captain, seven have been scores of 140 or more, while just one of his seven centuries he posted when he wasn’t been captain topped the 120 mark.It’s a record the skipper himself is fully aware of and says he made a conscious effort to turn all of his centuries into big, match-winning performances.“I think because of captaincy you tend to go on more than what you usually would as a normal batsman,” Kohli told BCCI.TV.“The room for complacency is no more present when you become captain.“That has something to do with me playing long innings. I have always wanted to play long innings and my first seven or eight hundreds were not even 120-plus scores.“After that I made a conscious effort to bat long, control my excitement or not be complacent.“I have worked on my fitness as well over the years. I feel like I can go on for longer periods now.“I don’t feel tired easily, and I definitely don’t get satisfied when I get a Test hundred.”“The way he’s batting, he’s going to rewrite the whole record book.“Most of the batting records, if not all of the batting records, are going to be his the way he’s going about scoring runs and scoring big runs in all forms of the game.”Azharuddin, who scored 22 centuries in 99 Tests for India, agreed that most batting records were well within reach of a man whose thirst for runs seems unquenchable.“Records are meant to be broken and I think the form he is (in) at the moment most batting records will tumble,” Azharuddin told xtratime.in.“The hallmark of a great player is to do well in any condition and under any situation. Virat has proved that time and again in recent times.“The one thing that stays apart for me is his ability to stay focused and score runs in any format consistently.“He is well aware of what is happening and has the ability to read the situation.”Kohli’s double centuries against the West Indies, New Zealand, England (all last year) and now Bangladesh are his first in Test cricket having previously passed 150 just twice in his career.Of his nine centuries he has scored as captain, seven have been scores of 140 or more, while just one of his seven centuries he posted when he wasn’t been captain topped the 120 mark.It’s a record the skipper himself is fully aware of and says he made a conscious effort to turn all of his centuries into big, match-winning performances.“I think because of captaincy you tend to go on more than what you usually would as a normal batsman,” Kohli told BCCI.TV.“The room for complacency is no more present when you become captain.“That has something to do with me playing long innings. I have always wanted to play long innings and my first seven or eight hundreds were not even 120-plus scores.“After that I made a conscious effort to bat long, control my excitement or not be complacent.“I have worked on my fitness as well over the years. I feel like I can go on for longer periods now.“I don’t feel tired easily, and I definitely don’t get satisfied when I get a Test hundred.”Gavaskar said the Australians had every right to be fearful of the Indian superstar as they seek to reverse their poor recent record in the subcontinent over the coming weeks.“Four double hundreds in four consecutive series against four different oppositions and there’s still Australia to come,” Gavaskar said.“The mind just boggles at the thought of what is going to happen in the next four Test matches.”last_img read more

Mavericks Kitty Group Golf Tournament Tees-off Today

first_img“The Mavericks kitty group under the leadership of AVM Hassan Aliyu with 25 members within the golf section decided to organise the tournament for all members of BCGS, with the purpose of mutually enjoying the game of golf and promotes the aspirations not only for golf section but of Benin Club as a whole.“There are lots of golf related trophies and other prizes to be won by all those who distinguished themselves in various categories at the event.“This edition is a closed tournament for BCGS members only, but there is a plan to make it an open tournament to other golfers across the country next year. The group comprises of people of like mind similar to The Lord’s group, Jami-Jami group, and Solid golf group within the club, Iyare said. “Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Mavericks Kitty Group End of the Year Golf Tournament will tee-off today with about 80 golfers participating at the event.The tournament slated for Benin Club golf section’s golf course, GRA Benin City, Edo State is organised by the Mavericks kitty group in conjunction with BCGS is for the purpose of mutually enjoying the game of golf, and to promote the aspirations of all members of Benin Club.The group competition secretary, Air Commodore Oscar Iyare, noted that about 80 members within the golf section are participating at the tournament and it will feature men’s, ladies, veteran and super veteran category as well as regular men, and Mavericks members respectively.last_img read more

Girls volleyball Bees fall just short of state Class AA title

first_imgA decade that started with a landmark state championship for the Baldwinsville girls volleyball team concluded with the Bees chasing that exact same prize for the third time, only to get denied at the last hurdle.The Bees fought its way to Sunday’s New York State Public High School Athletic Association Class AA title match at Glens Falls’ Cool Insuring Arena before Long Island powerhouse Connetquot stopped them in a three-set decision.In the years since it claimed a second state title in 2013, B’ville had continued to make Section III titles an annual occurrence, but had found it more difficult just to make it back to the state final four. Yet it was Mercy fighting back to take the second set 25-21, and then, facing Connetquot, the Bees lost the opening set to the Thunderbirds 25-19. If it didn’t win the second set, B’ville would have to go through a tie-breaker with Mercy.But since Connetquot had already advanced to the final, it didn’t need the second set, and B’ville had little trouble claiming the second set 25-11 to earn a rematch with the Thunderbirds the next afternoon.From the start of the championship match, Connetquot asserted control through its power at the net and with strong serves. Down 6-1, the Bees traded point for a while, but the Thunderbirds got away and claimed that set 25-12.For a brief moment in the second set, B’ville grabbed a 5-4 lead, and stayed within range for a while even when Connetquot got the lead. Just as in the first set, though, the Thunderbirds would prove too touch and claim a 25-17 decision.All through the third set, any time the Bees tried to put together any sort of run, Connetquot shut it down and pulled further away. By a 25-16 margin, the Thunderbirds earned its third state championship to match those it earned in 2015 and 2017.As for B’ville, it will see eight seniors graduate, including Rileigh Kimball, Summer McClintic, Sophia Kordas, Maddie Shuler and Jenna Wallace, but returns key players like Brooke Clute, Jenna Garvey and Kyrah Wilbur in 2020.Share this:FacebookTwitterLinkedInRedditComment on this Story However, that hurdle was cleared on Nov. 16 when the Bees swept Niskayuna in the AA regional final at Jamesville-DeWitt. Now, back in Glens Falls, the Bees not only had to deal with Connetquot, but Section I’s Ossining and Section V’s Rochester Mercy.It could not have started better late on Saturday afternoon, B’ville taking on Ossining first in round-robin play. The Bees comfortably topped the Pride 25-18 in the first set and then pulled off a 25-11 rout in the second set.Mercy was next, and the Bees scored the first six points against the Monarchs and built a 16-4 advantage before cruising to the 25-14 victory. One more set victory would clinch a state finals berth.center_img Tags: Baldwinsvillegirls volleyballlast_img read more